Tatil Tatlılarına Fazla Doymuş Musunuz? Bioelektronik Uyarıcılar Yakında Yardımcı Olabilir

Today, an increasing amount of people are living an increasingly sedentary and gluttonous lifestyle.  Whether this is due to more screen time, work-from-home practices, or something else entirely, the result is the same – Obesity has become an epidemic.  While smoking topped the list of leading causes of preventable deaths for ages, it was in the 1990s that Obesity began to vie for this unwanted moniker.  By the 2000s, it became the number one cause of preventable deaths and has stayed atop the list ever since.  As a result, pharmaceutical companies and biotech researchers have been hard at work ever since, developing solutions for dealing with the situation.  One of the latest approaches involves ‘bioelectronic stimulators’ that look to trick the brain into thinking one is full when ingested.

Bioelektronik Uyarıcıları Anlamak

In a recent paper titled “Vibrasyonlu yutulabilir bioelektronik uyarıcı, illüzyonel tokluk“, released through science.org, researchers detail a new approach to tackling obesity.  Rather than attempting to manipulate the body’s endocrine system or through “invasive surgical and endoscopic interventions,” this approach makes use of what they call ‘bioelectronic stimulators’ – essentially pills that vibrate while in the stomach that are safe to pass through the gastrointestinal tract.
The purpose of these pills, which the researchers call the “Vibrating Ingestible BioElectronic Stimulator (VIBES)”, is to stimulate nerve endings within the stomach lining that play a role in ‘feeling full’.  While human trials have not yet begun, it is shared that early tests were highly successful in decreasing intake among pigs by as much as 40%.  The study provides the following description of the process involved with these pills.

“VIBES, ağız yoluyla alınacak şekilde, mide zarıyla temasını sürdürecek, mide sıvısına daldırıldığında aktive olacak, belirli bir süre boyunca mide IGLE’lerini uyarmak için yeterli genlikte titreşecek ve gastrointestinal sistemden güvenle geçecek şekilde tasarlanmıştır.”

It should be noted that while VIBES may represent a gentler approach to obesity than existing options at this time, these tests were completed with pigs and not humans.  It should be interesting moving forward to see if such an approach can be brought to fruition, as effective obesity treatments have already proven both life-changing for users and Novo Nordisk gibi şirketler için son derece kârlı olduğunu kanıtlamıştır.

Obezite Neden Bu Kadar Kötü?

What makes Obesity so terrible is the strain that it puts on not only the healthcare system but each and every system within the human body.  Increased fat leads to atherosclerosis, which results in strokes, heart attacks, high blood pressure, and more.  It is also typically accompanied by diabetes, which means nerve issues, gait issues, sugar comas, and ketoacidosis.  It results in systemic inflammation, acid reflux, and more.  The list goes on and on and on.
Another reason it has become so dangerous is one that is not as commonly discussed (and often derided when it is) – normalization.  There are always exceptions that may result in obesity being out of a person’s control.  However, the fact that 42% of North Americans live with it, alongside an age that promotes acceptance of all body types, has resulted in obesity being viewed in a normal light.  This means that not only is obesity accompanied by a litany of terrible health ailments, is has become prevalent with a decreased awareness surrounding the need to do something about it.

Mevcut Çözümler?

On paper, the solution to obesity looks simple enough – burn more calories than you take in.  Traditionally, this means eating less, eating healthy, and exercising more.  This isn’t always possible though, which has resulted in various other solutions being developed over the years.  The following are examples of these.

Cerrahi: En aşırı durumlarda, bazı bireyler gastrik bypass veya gastrik bantlama gibi cerrahi çözümlere yönelir.  Bu genellikle mide boyutunun kısıtlanmasını ve aşırı yemek yemeyi önlemeyi içerir.

İlaçlar: İnvaziv cerrahiler düşünülmeden önce, birçok kişi artık semaglutid (örneğin Ozempic ve Wegovy) gibi farmasötik çözümlere yöneliyor.  Bu tür ilaçlar, endokrin sistemi ve iştah, sindirim ve kan şekeri üzerindeki etkisini manipüle ederek çalışır.

Naturally, each of these approaches can have major side-effects of their own, making the preferred approach towards obesity lifestyle changes instead.

En İyi Biyotek Şirketleri

As it stands, a bioelectronic stimulator used to decrease appetite is nothing more than a potential solution to obesity.  The issue remains, however, and pharmaceutical companies are hard at work developing effective approaches like semaglutide.  The following are a few examples of these.

*Aşağıda verilen rakamlar yazım anında doğruydu ve değişikliğe tabi olabilir.  Potansiyel yatırımcıların metrikleri doğrulamaları önerilir*

1. Novo Nordisk

NVO Fiyat Grafiği

Novo Nordisk, özellikle FDA onaylı kilo kaybı enjeksiyon tedavisi Wegovy ile obezite tedavi pazarında önemli ilerlemeler kaydetti.  Şirketin obezite bakım ürünlerinden elde ettiği satışlar, 2023’ün ilk dokuz ayında %174 artarak obezite tedavilerine olan yüksek talebi yansıttı.

2. Pfizer, Inc.

PFE Fiyat Grafiği

Pfizer (PFE ), Novartis ve Amgen (AMGN ) gibi diğer büyük ilaç şirketleriyle birlikte, kendi obezite tedavilerini aktif olarak geliştiriyor.  2030 yılına kadar 100 milyar dolar ulaşması öngörülen anti-obezite ilaç pazarı potansiyeli, bu şirketlerin obezite çözümleri geliştirmek için yatırım yapmasını çekmiştir.

3. Eli Lilly and Company

LLY Fiyat Grafiği

Eli Lilly and Company (LLY ), FDA onayı alan Zepbound™ (tirzepatide) enjeksiyonunu geliştirdi.  Bu tedavi, hem GIP (glukoz-bağımlı insülinotropik polipeptid) hem de GLP-1 (glukagon benzeri peptid-1) hormon reseptörlerini aktive eden ilk tür olmasıyla dikkat çekiyor ve obezite tedavileri yelpazesine benzersiz bir ek sağlıyor.